Disorders under this qualification generally tend to be inherited and/or genetic disorders which lead to disability by interfering with a person’s ability to ambulate in a typical manner.  They lead to symptoms such as uncontrollable muscle spasms and uncoordinated and difficult movement of commonly used muscles, sometimes causing the afflicted to appear odd to the uninformed general populace. Tourette syndrome is a classic example of a condition that falls under this categorization.

Medical marijuana typically helps patients with these condition by decreasing spasticty, promoting muscle relaxation, decreasing inflammation and providing some neuropathic pain relief.