Sure, there are some adverse effects of heavy chronic use, like coughing or mucus but those go away and just think of the Rastas from Jamaica with traditional sacred herb consumed daily through chalices. They’re healthier than Americans and look at how much we’re paying for healthcare! Or, look up NSAIDs on Wikipedia. Compare the adverse effects for long-term and it’s like black and white, yet these are the most common medications for pain (Alleve, Advil, etc.). It’s easier to say there’s no long term adverse effects at this point and leave the onus on the literature to prove otherwise. That’s my opinion and I’m sticking to it. This is smoking we’re mainly talking about; we haven’t even gotten into safer methods of consumption like Pennsylvania established. Blessing in disguise….